Exploring titanium(IV) chemical proximity to iron(III) to elucidate a function for Ti(IV) in the human body.

ABSTRACT: Despite its natural abundance and widespread use as food, paint additive, and in bone implants, no specific biological function of titanium is known in the human body. High concentrations of Ti(IV) could result in cellular toxicity, however, the absence of Ti toxicity in the blood of patients with titanium bone implants indicates the presence of one or more biological mechanisms to mitigate toxicity. Similar to Fe(III), Ti(IV) in blood binds to the iron transport protein serum transferrin (sTf), which gives credence to the possibility of its cellular uptake mechanism by transferrin-directed endocytosis. However, once inside the cell, how sTf bound Ti(IV) is released into the cytoplasm, utilized, or stored remain largely unknown. To explain the molecular mechanisms involved in Ti use in cel

SUBMITTER: Saxena M 

PROVIDER: S-EPMC6159949 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature