Systematic meta-analysis of genetic variants associated with osteosarcoma susceptibility.

ABSTRACT:

Background

In the past decade, accumulated evidence has suggested that genetic variation is related to the pathogenesis of osteosarcoma. Although there are a large number of studies on the association between genetic variation and osteosarcoma, their results are inconsistent. To clarify these findings, we performed a systematic meta-analysis using allelic contrasts for each gene-specific single nucleotide variants with all available data in the field of osteosarcoma.

Methods

The literature search for relevant studies was conducted in PubMed, Embase, and Cochrane databases. Pooled ORs and 95% CI values were calculated by the random-effects model using the Comprehensive Meta-analysis version 2.0 software package. Heterogeneity between studies was examined by the Cochran's Q-te

SUBMITTER: Wang X 

PROVIDER: S-EPMC6160068 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature