Association of metformin administration with gut microbiome dysbiosis in healthy volunteers.

ABSTRACT:

Background

Metformin is a widely used first-line drug for treatment of type 2 diabetes. Despite its advantages, metformin has variable therapeutic effects, contraindications, and side effects. Here, for the very first time, we investigate the short-term effect of metformin on the composition of healthy human gut microbiota.

Methods

We used an exploratory longitudinal study design in which the first sample from an individual was the control for further samples. Eighteen healthy individuals were treated with metformin (2 × 850 mg) for 7 days. Stool samples were collected at three time points: prior to administration, 24 hours and 7 days after metformin administration. Taxonomic composition of the gut microbiome was analyzed by massive parallel sequencing of 16S rRNA gene (V3 r

SUBMITTER: Elbere I 

PROVIDER: S-EPMC6160085 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature