Congenital heart defect repair with ADAPT tissue engineered pericardium scaffold: An early-stage health economic model.

ABSTRACT:

Objective

The objective of this study was to evaluate the cost effectiveness of tissue engineered bovine tissue pericardium scaffold (CardioCel) for the repair of congenital heart defects in comparison with surgery using xenogeneic, autologous, and synthetic patches over a 40-year time horizon from the perspective of the UK National Health Service.

Methods

A six-state Markov state-transition model to model natural history of disease and difference in the interventional effect of surgeries depending on patch type implanted. Patches differed regarding their probability of re-operation due to patch calcification, based on a systematic literature review. Transition probabilities were based on the published literature, other clinical inputs were based on UK registry data, and cos

SUBMITTER: Velickovic VM 

PROVIDER: S-EPMC6160133 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature