Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages.

ABSTRACT: We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64-90 Hz power. In contrast, FEP- and ScZ-patients showed aberrant spectral power at both low- and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital g

SUBMITTER: Grent-'t-Jong T 

PROVIDER: S-EPMC6160226 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature