Plasma metabolite profiles in children with current asthma.

ABSTRACT:

Background

Identifying metabolomic profiles of children with asthma has the potential to increase understanding of asthma pathophysiology.

Objective

To identify differences in plasma metabolites between children with and without current asthma at mid-childhood.

Methods

We used untargeted mass spectrometry to measure plasma metabolites in 237 children (46 current asthma cases and 191 controls) in Project Viva, a birth cohort from eastern Massachusetts, USA. Current asthma was assessed at mid-childhood (mean age 8.0 years). The ability of a broad spectrum metabolic profile to distinguish between cases and controls was assessed using partial least squares discriminant analysis. We used logistic regression models to identify individual metabolites that were differentially

SUBMITTER: Kelly RS 

PROVIDER: S-EPMC6160355 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature