Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias.

ABSTRACT:

Background

Left atrium (LA) physiology is influenced by changes in left ventricular (LV) performance and load.

Objectives

The purpose of this study was to define the effect of acute changes in LV loading conditions on LA physiology in subacute myocardial infarction (MI).

Methods

MI was percutaneously induced in 19 Yorkshire pigs. One to 2 weeks after MI, 14 pigs underwent acute LV unloading using a percutaneous LV assist device, Impella. The remaining 5 pigs underwent acute LV loading by percutaneous induction of aortic regurgitation. A pressure-volume catheter was inserted into the LA using a percutaneous transseptal approach, and LA pressure-volume loops were continuously monitored. Atrial arrhythmia inducibility was examined by burst-pacing of the right atrium. Nic

SUBMITTER: Ishikawa K 

PROVIDER: S-EPMC6160394 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature