Specificity of the osmotic stress response in Candida albicans highlighted by quantitative proteomics.

ABSTRACT: Stress adaptation is critical for the survival of microbes in dynamic environments, and in particular, for fungal pathogens to survive in and colonise host niches. Proteomic analyses have the potential to significantly enhance our understanding of these adaptive responses by providing insight into post-transcriptional regulatory mechanisms that contribute to the outputs, as well as testing presumptions about the regulation of protein levels based on transcript profiling. Here, we used label-free, quantitative mass spectrometry to re-examine the response of the major fungal pathogen of humans, Candida albicans, to osmotic stress. Of the 1,262 proteins that were identified, 84 were down-regulated in response to 1M NaCl, reflecting the decrease in ribosome biogenesis and translation that ofte

SUBMITTER: Jacobsen MD 

PROVIDER: S-EPMC6160413 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature