Immunological correlates of mycobacterial growth inhibition describe a spectrum of tuberculosis infection.

ABSTRACT: A major contribution to the burden of Tuberculosis (TB) comes from latent Mycobacterium tuberculosis infections (LTBI) becoming clinically active. TB and LTBI probably exist as a spectrum and currently there are no correlates available to identify individuals with LTBI most at risk of developing active disease. We set out to identify immune parameters associated with ex vivo mycobacterial growth control among individuals with active TB disease or LTBI to define the spectrum of TB infection. We used a whole blood mycobacterial growth inhibition assay to generate a functional profile of growth control among individuals with TB, LTBI or uninfected controls. We subsequently used a multi-platform approach to identify an immune signature associated with this profile. We show, for the first time,

SUBMITTER: O'Shea MK 

PROVIDER: S-EPMC6160428 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature