Altered physiological brain variation in drug-resistant epilepsy.

ABSTRACT:

Introduction

Functional magnetic resonance imaging (fMRI) combined with simultaneous electroencephalography (EEG-fMRI) has become a major tool in mapping epilepsy sources. In the absence of detectable epileptiform activity, the resting state fMRI may still detect changes in the blood oxygen level-dependent signal, suggesting intrinsic alterations in the underlying brain physiology.

Methods

In this study, we used coefficient of variation (CV) of critically sampled 10 Hz ultra-fast fMRI (magnetoencephalography, MREG) signal to compare physiological variance between healthy controls (n = 10) and patients (n = 10) with drug-resistant epilepsy (DRE).

Results

We showed highly significant voxel-level (p < 0.01, TFCE-corrected) increase in the physiological variance in DRE pa

SUBMITTER: Kananen J 

PROVIDER: S-EPMC6160661 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature