Simultaneous characterization of tumor cellularity and the Warburg effect with PET, MRI and hyperpolarized ¹³C-MRSI.

ABSTRACT: Modern oncology aims at patient-specific therapy approaches, which triggered the development of biomedical imaging techniques to synergistically address tumor biology at the cellular and molecular level. PET/MR is a new hybrid modality that allows acquisition of high-resolution anatomic images and quantification of functional and metabolic information at the same time. Key steps of the Warburg effect-one of the hallmarks of tumors-can be measured non-invasively with this emerging technique. The aim of this study was to quantify and compare simultaneously imaged augmented glucose uptake and LDH activity in a subcutaneous breast cancer model in rats (MAT-B-III) and to study the effect of varying tumor cellularity on image-derived metabolic information. Methods: For this purpose, we es

SUBMITTER: Hundshammer C 

PROVIDER: S-EPMC6160766 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature