Senescent fibroblasts drive ageing pigmentation: ​A potential therapeutic target for senile lentigo.

ABSTRACT: Cutaneous ageing is an important extrinsic process that modifies the pigmentary system. Because cellular senescence is a fundamental ageing mechanism, we examined the role of senescent cells in ageing pigmentation. Methods: Biopsies obtained from senile lentigo and perilesional normal skin were assayed for a marker of cellular senescence, p16^INK4A. To determine the secretory phenotypes of senescent fibroblasts, we performed microarray, RNA sequencing and methylation array analyses in senile lentigo and senescent fibroblasts. To further investigate the impact of senescent cells on ageing-related pigmentation, an intervention that targeted senescent cells using radiofrequency was performed. Results:In vivo, senescent fibroblasts accumulated at the sites of age

SUBMITTER: Yoon JE 

PROVIDER: S-EPMC6160768 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature