Dataset Information
MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain.
Ontology highlight
ABSTRACT:
SUBMITTER: Kovacs ZI
PROVIDER: S-EPMC6160777 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain.
Theranostics 20180909 17
Magnetic resonance imaging (MRI)-guided pulsed focused ultrasound (pFUS) combined with microbubbles (MB) contrast agent infusion has been shown to transiently disrupt the blood-brain barrier (BBBD), increasing the delivery of neurotherapeutics to treat central nervous system (CNS) diseases. pFUS interaction with the intravascular MB results in acoustic cavitation forces passing through the neurovascular unit (NVU), inducing BBBD detected on contrast-enhanced MRI. Multiple pFUS+MB exposures in Al ...[more]
