In Silico Structural Evaluation of Short Cationic Antimicrobial Peptides.

ABSTRACT: Cationic peptides with antimicrobial properties are ubiquitous in nature and have been studied for many years in an attempt to design novel antibiotics. However, very few molecules are used in the clinic so far, sometimes due to their complexity but, mostly, as a consequence of the unfavorable pharmacokinetic profile associated with peptides. The aim of this work is to investigate cationic peptides in order to identify common structural features which could be useful for the design of small peptides or peptido-mimetics with improved drug-like properties and activity against Gram negative bacteria. Two sets of cationic peptides (AMPs) with known antimicrobial activity have been investigated. The first reference set comprised molecules with experimentally-known conformations available in the

SUBMITTER: Passarini I 

PROVIDER: S-EPMC6160961 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature