The Immunity Gap Challenge: Protection against a Recent Florida Clade 2 Equine Influenza Strain.

ABSTRACT: Vaccination is one of the most effective tools for limiting the impact of equine influenza (EI). The humoral immunity established following a primary vaccination course can decrease significantly between the second (V2) and third immunisations (V3), leaving some horses insufficiently protected for several weeks. This so-called "immunity gap" poses a challenge to all EI vaccines. During this period, the EI infection of vaccinated animals may be followed by marked clinical signs and virus shedding. However, several EI vaccines have been shown to stimulate equine influenza virus (EIV)-specific cell-mediated immunity, which is likely to play a role in protection against EIV infection and/or mitigate the clinical and virological signs of EI. Reducing the interval between V2 and V3 has been show

SUBMITTER: Paillot R 

PROVIDER: S-EPMC6161116 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature