SDH2 is involved in proper hypha formation and virulence in Candida albicans.

ABSTRACT: AIM:To investigate the role of SDH2 in Candida albicans filamentation and virulence. MATERIALS & METHODS:Caenorhabditis elegans and mouse candidiasis models were used to assess the virulence of a sdh2Δ/Δ mutant. Various hypha-inducing media were used to evaluate the hyphal development of C. albicans. DCFH-DA was used to measure intracellular Reactive Oxygen Species (ROS) levels. RESULTS:The sdh2Δ/Δ mutant was avirulent in the C. elegans model, hypovirulent in a murine candidiasis model, and defective to form filaments both in vitro and in vivo. Intracellular ROS level increased in the sdh2Δ/Δ mutant, and the filamentation defects of sdh2Δ/Δ were rescued by decreasing intracellular ROS. CONCLUSION:SDH2 plays an important role in C. albicans filamentation and virulence probably through affec

SUBMITTER: Bi S 

PROVIDER: S-EPMC6161146 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature