Looking for Novel Capsid Protein Multimerization Inhibitors of Feline Immunodeficiency Virus.

ABSTRACT: Feline immunodeficiency virus (FIV) is a member of the retroviridae family of viruses. It causes acquired immunodeficiency syndrome (AIDS) in worldwide domestic and non-domestic cats and is a cause of an important veterinary issue. The genome organization of FIV and the clinical characteristics of the disease caused by FIV are similar to human immunodeficiency virus (HIV). Both viruses infect T lymphocytes, monocytes, and macrophages, with a similar replication cycle in infected cells. Thus, the infection of cats with FIV is also a useful tool for the study and development of novel drugs and vaccines against HIV. Anti-retroviral drugs studied extensively with regards to HIV infection have targeted different steps of the virus replication cycle: (1) disruption of the interaction with host c

SUBMITTER: Sierra N 

PROVIDER: S-EPMC6161179 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature