Rheological and Mechanical Analyses of Felbinac Cataplasms by Using Box⁻Behnken Design.

ABSTRACT: Felbinac, an active pharmaceutical ingredient (API) used clinically for the treatment of osteoarthritis, has poor solubility. Felbinac cataplasm product design was investigated using rheological and mechanical analyses. Experiments using a response surface methodology based on Box⁻Behnken design (BBD) incorporated three independent variables: the proportions of partially neutralized polyacrylate (NP800), dihydroxyaluminum aminoacetate (DAAA), and felbinac. Statistically significant quadratic models obtained using BBD demonstrated optimal NP-800, DAAA, and felbinac cataplasm proportions of 4.78⁻5.75%, 0.30⁻0.59%, and 0.70⁻0.90%, respectively. Felbinac cataplasms exhibited "gel-like" mechanical property with predominantly elastic behavior. Rheological studies correlated increasing NP-800 and

SUBMITTER: Yang J 

PROVIDER: S-EPMC6161182 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature