Regional Diversity in the Postsynaptic Proteome of the Mouse Brain.

ABSTRACT: The proteome of the postsynaptic terminal of excitatory synapses comprises over one thousand proteins in vertebrate species and plays a central role in behavior and brain disease. The brain is organized into anatomically distinct regions and whether the synapse proteome differs across these regions is poorly understood. Postsynaptic proteomes were isolated from seven forebrain and hindbrain regions in mice and their composition determined using proteomic mass spectrometry. Seventy-four percent of proteins showed differential expression and each region displayed a unique compositional signature. These signatures correlated with the anatomical divisions of the brain and their embryological origins. Biochemical pathways controlling plasticity and disease, protein interaction networks and indi

SUBMITTER: Roy M 

PROVIDER: S-EPMC6161190 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature