Phylogenetic, comparative genomic and structural analyses of human Streptococcus agalactiae ST485 in China.

ABSTRACT:

Background

Streptococcus agalactiae (Group B Streptococcus, GBS) is a common bacteria species infecting both human and bovine. Previous studies have shown that the GBS isolated from human and bovine are mostly unrelated and belong to separate populations. However, recently, the bovine GBS CC103 has become the dominant epidemic strain and frequently isolated from human patients. In particular, the ST485 GBS, a member of CC103, has become the new dominant ST in China and exhibited very high pathogenicity. This phenomenon is not consistent with the established understanding about the relationship between bovine and human GBS, which needs to be re-investigated.

Results

The genome-based phylogenetic analysis showed that the human and bovine GBS CC103 strains had very close geneti

SUBMITTER: Wang R 

PROVIDER: S-EPMC6161333 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature