Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin.

ABSTRACT:

Background

Recombinant human soluble thrombomodulin (rTM) has been used for the treatment of disseminated intravascular coagulation in Japan, and an international phase III clinical trial for rTM is currently in progress. rTM mainly exerts its anticoagulant effects through an activated protein C (APC)-dependent mechanism, but the circulating APC levels after rTM treatment have not been clarified. This prospective observational study investigated plasma APC levels after rTM treatment.

Methods

Plasma levels of soluble thrombomodulin, thrombin-antithrombin complex (TAT), protein C, and APC were measured in eight septic patients treated with rTM. APC generation in vitro was assessed in the presence or absence of rTM.

Results

rTM significantly increased thrombin-mediated A

SUBMITTER: Arishima T 

PROVIDER: S-EPMC6161343 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature