A comprehensive analysis of 195 DNA methylomes reveals shared and cell-specific features of partially methylated domains.

ABSTRACT:

Background

Partially methylated domains are extended regions in the genome exhibiting a reduced average DNA methylation level. They cover gene-poor and transcriptionally inactive regions and tend to be heterochromatic. We present a comprehensive comparative analysis of partially methylated domains in human and mouse cells, to identify structural and functional features associated with them.

Results

Partially methylated domains are present in up to 75% of the genome in human and mouse cells irrespective of their tissue or cell origin. Each cell type has a distinct set of partially methylated domains, and genes expressed in such domains show a strong cell type effect. The methylation level varies between cell types with a more pronounced effect in differentiating and replicati

SUBMITTER: Salhab A 

PROVIDER: S-EPMC6161375 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature