Biomarkers Associated with Tumor Heterogeneity in Prostate Cancer.

ABSTRACT:

Background

Prostate cancers exhibit intratumor heterogeneity (ITH), like other cancer types. The ITH may affect diverse phenotypes such as treatment response, drug resistance, and clinical outcomes. It is crucial to consider ITH to understand tumorigenesis.

Methods

Genomic and transcriptomic profiles of prostate cancer patients were investigated to determine which markers are correlated with the degree of tumor heterogeneity. In addition, the correlation between the immune activity and clonality of tumors was examined.

Results

Tumor heterogeneity across all prostate cancer samples was variable. However, ITH events were dependent on genomic and clinical features. Interestingly, prostate-specific antigen score increased in tumors with multiple subclones, indicating high

SUBMITTER: Yun JW 

PROVIDER: S-EPMC6161410 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature