Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control study.

ABSTRACT:

Background

Bile acid metabolism plays an important role in metabolism but it is uncertain whether bile acid metabolites in early pregnancy are associated with risk of gestational diabetes mellitus (GDM).

Methods

We organized a 1:1 case-control study nested in a prospective cohort of 22,302 pregnant women recruited from 2010 to 2012 in China: 243 women with GDM were matched with 243 non-GDM controls on age (±1 year). Conditional logistic regression and restricted cubic spline were used to examine full-range associations of bile acid metabolites with GDM.

Findings

All the 9 detectable bile acids were inversely associated with the risk of GDM, among them, 8 in nonlinear and one in largely linear manners in multivariable analysis. Glycoursodeoxycholic acid (GUDCA) at ≤0.0

SUBMITTER: Li J 

PROVIDER: S-EPMC6161472 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature