Impact of host-pathogen-treatment tripartite components on early mortality of patients with Escherichia coli bloodstream infection: Prospective observational study.

ABSTRACT:

Background

Risk factors affecting early morality of patients with Escherichia coli bloodstream infection (BSI) were investigated including the host-pathogen-treatment tripartite components.

Methods

Six general hospitals in South Korea participated in this multicentre prospective observational study from May 2016 to April 2017 and a total of 1492 laboratory-confirmed E. coli BSI cases were studied. Cox regression was used to estimate risks of the primary endpoint, i.e., all-cause mortality within 30 days from the initial blood culture. Six multivariate analysis models were constructed in accordance to the clinical importance and intra- and inter-component multicollinearity.

Findings

Among the 1492 E. coli BSI cases, 9.5% (n = 141) patients expired within 30 days. Six m

SUBMITTER: Yoon EJ 

PROVIDER: S-EPMC6161478 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature