APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology.

ABSTRACT:

Objective

To evaluate whether APOE ε4 is associated with severity of Lewy body (LB) pathology, independently of Alzheimer disease (AD) pathology.

Methods

Six hundred fifty-two autopsy-confirmed LB disease (LBD) cases and 660 clinical controls were genotyped for APOE. In case-control analysis, LBD cases were classified into 9 different groups according to severity of both LB pathology (brainstem, transitional, diffuse) and AD pathology (low, moderate, high) to assess associations between APOE ε4 and risk of different neuropathologically defined LBD subgroups in comparison to controls. In LBD cases only, we also measured LB counts from 5 cortical regions and evaluated associations with ε4 according to severity of AD pathology.

Results

As expected, <

SUBMITTER: Dickson DW 

PROVIDER: S-EPMC6161556 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature