A Computational Framework to Benchmark Basket Catheter Guided Ablation in Atrial Fibrillation.

ABSTRACT: Catheter ablation is a curative therapeutic approach for atrial fibrillation (AF). Ablation of rotational sources based on basket catheter measurements has been proposed as a promising approach in patients with persistent AF to complement pulmonary vein isolation. However, clinically reported success rates are equivocal calling for a mechanistic investigation under controlled conditions. We present a computational framework to benchmark ablation strategies considering the whole cycle from excitation propagation to electrogram acquisition and processing to virtual therapy. Fibrillation was induced in a patient-specific 3D volumetric model of the left atrium, which was homogeneously remodeled to sustain reentry. The resulting extracellular potential field was sampled using models of grid cat

SUBMITTER: Alessandrini M 

PROVIDER: S-EPMC6161611 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature