Fine mapping MHC associations in Graves' disease and its clinical subtypes in Han Chinese.

ABSTRACT:

Background

The classical human leucocyte antigen (HLA) genes were the most important genetic determinant for Graves' disease (GD). The aim of the study was to fine map causal variants of the HLA genes.

Methods

We applied imputation with a Pan-Asian HLA reference panel to thoroughly investigate themajor histocompatibility complex (MHC) associations with GD down to the amino acid level of classical HLA genes in 1468 patients with GD and 1490 controls of Han Chinese.

Results

The strongest finding across the HLA genes was the association with HLA-DPβ1 position 205 (P_omnibus=2.48×10^-33). HLA-DPA1*02:02 was the strongest association among the classical HLA alleles, which was in perfect linkage disequilibrium with HLA-DPα1 residue Met11 (O

SUBMITTER: Chu X 

PROVIDER: S-EPMC6161647 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature