MiRNA-BD: an evidence-based bioinformatics model and software tool for microRNA biomarker discovery.

ABSTRACT: MicroRNAs (miRNAs) are small non-coding RNAs with the potential as biomarkers for disease diagnosis, prognosis and therapy. In the era of big data and biomedical informatics, computer-aided biomarker discovery has become the current frontier. However, most of the computational models are highly dependent on specific prior knowledge and training-testing procedures, very few are mechanism-guided or evidence-based. To the best of our knowledge, untill now no general rules have been uncovered and applied to miRNA biomarker screening. In this study, we manually collected literature-reported cancer miRNA biomarkers and analyzed their regulatory patterns, including the regulatory modes, biological functions and evolutionary characteristics of their targets in the human miRNA-mRNA network. Two evi

SUBMITTER: Lin Y 

PROVIDER: S-EPMC6161673 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature