Using bioinformatics tools for the discovery of Dengue RNA-dependent RNA polymerase inhibitors.

ABSTRACT:

Background

Dengue fever has rapidly manifested into a serious global health concern. The emergence of various viral serotypes has prompted the urgent need for innovative drug design techniques. Of the viral non-structural enzymes, the NS5 RNA-dependent RNA polymerase has been established as a promising target due to its lack of an enzymatic counterpart in mammalian cells and its conserved structure amongst all serotypes. The onus is now on scientists to probe further into understanding this enzyme and its mechanism of action. The field of bioinformatics has evolved greatly over recent decades, with updated drug design tools now being publically available.

Methods

In this study, bioinformatics tools were used to provide a comprehensive sequence and structural analysis of the

SUBMITTER: Nncube NB 

PROVIDER: S-EPMC6161702 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature