DM-Dim for Carboxylic Acid Protection.

ABSTRACT: The 1,3-dithian-2-yl-methyl (Dim) and its analogous groups including dimethyl-Dim (dM-Dim) can provide a new dimension of orthogonality for carboxylic acid protection. They can be deprotected under nearly neutral oxidative conditions. In this paper, the protection of carboxylic acid with dM-Dim, deprotection of dM-Dim ester with sodium periodate, stability of dM-Dim protected carboxylic acid under acidic and basic conditions, and selective deprotection of dM-Dim protected carboxylic acids in the presence of tertiary butyl and methyl esters are presented.

SUBMITTER: Shahsavari S 

PROVIDER: S-EPMC6161831 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature