BVES is required for maintenance of colonic epithelial integrity in experimental colitis by modifying intestinal permeability.

ABSTRACT: Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. There have been no in vivo studies investigating the role of BVES in colitis. We hypothesized that BVES is critical for maintaining colonic epithelial integrity. At baseline, Bves^-/- mouse colons demonstrate increased crypt height, elevated proliferation, decreased apoptosis, altered intestinal lineage allocation, and dysregulation of tight junctions with functional deficits in permeability and altered intestinal immunity. Bves^-/- mice inoculated with Citrobacter rodentium had greater colonic injury, increased colonic and mesenteric lymph node bacterial colonization, and a

SUBMITTER: Choksi YA 

PROVIDER: S-EPMC6162166 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature