Significance of re-biopsy for recurrent breast cancer in the immune tumour microenvironment.

ABSTRACT:

Background

Immune responses in a tumour microenvironment can be evaluated by analysing tumour-infiltrating lymphocyte (TIL) density; this has been verified in the clinical setting. Although there are many reports on TIL density in primary tumours, little is known about its density in recurrent tumours.

Methods

Of 300 patients treated with neoadjuvant chemotherapy during the study period, 29 were considered for evaluation of TIL density in primary and recurrent tumours. We performed a retrospective analysis of the association between TIL density and prognosis.

Results

TIL density was significantly lower in recurrent tumours than in primary tumours (P = 0.007). There was no correlation between post-recurrence survival and TIL density in core-needle biopsy specimens obta

SUBMITTER: Takada K 

PROVIDER: S-EPMC6162217 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature