Inhibition-excitation balance in the parietal cortex modulates volitional control for auditory and visual multistability.

ABSTRACT: Perceptual organisation must select one interpretation from several alternatives to guide behaviour. Computational models suggest that this could be achieved through an interplay between inhibition and excitation across competing types of neural population coding for each interpretation. Here, to test for such models, we used magnetic resonance spectroscopy to measure non-invasively the concentrations of inhibitory γ-aminobutyric acid (GABA) and excitatory glutamate-glutamine (Glx) in several brain regions. Human participants first performed auditory and visual multistability tasks that produced spontaneous switching between percepts. Then, we observed that longer percept durations during behaviour were associated with higher GABA/Glx ratios in the sensory area coding for each modality. Wh

SUBMITTER: Kondo HM 

PROVIDER: S-EPMC6162284 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature