MTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis.

ABSTRACT: Skeletal osteoblasts are important regulators of B-lymphopoiesis, serving as a rich source of factors such as CXCL12 and IL-7 which are crucial for B-cell development. Recent studies from our laboratory and others have shown that deletion of Rptor, a unique component of the mTORC1 nutrient-sensing complex, early in the osteoblast lineage development results in defective bone development in mice. In this study, we now demonstrate that mTORC1 signalling in pre-osteoblasts is required for normal B-lymphocyte development in mice. Targeted deletion of Rptor in osterix-expressing pre-osteoblasts (Rptor_ob^-/-) leads to a significant reduction in the number of B-cells in the bone marrow, peripheral blood and spleen at 4 and 12 weeks of age. Rptor_ob^-/- mic

SUBMITTER: Martin SK 

PROVIDER: S-EPMC6162303 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature