Capturing the applicability of in vitro-in silico membrane transporter data in chemical risk assessment and biomedical research.

ABSTRACT: Costs, scientific and ethical concerns related to animal tests for regulatory decision-making have stimulated the development of alternative methods. When applying alternative approaches, kinetics have been identified as a key element to consider. Membrane transporters affect the kinetic processes of absorption, distribution, metabolism and excretion (ADME) of various compounds, such as drugs or environmental chemicals. Therefore, pharmaceutical scientists have intensively studied transporters impacting drug efficacy and safety. Besides pharmacokinetics, transporters are considered as major determinant of toxicokinetics, potentially representing an essential piece of information in chemical risk assessment. To capture the applicability of transporter data for kinetic-based risk assessment

SUBMITTER: Clerbaux LA 

PROVIDER: S-EPMC6162338 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature