A Dietary Intervention to Lower Serum Levels of IGF-I in BRCA Mutation Carriers.

ABSTRACT: Insulin-like growth factor I (IGF-I) and other markers of insulin resistance (IRm) might influence the penetrance of BRCA gene mutation. In a demonstration project on BRCA mutation carriers we tested the effect of the 'Mediterranean diet', with moderate protein restriction, on serum levels of IGF-I and IRm. BRCA mutation carriers, with or without breast cancer, aged 18⁻70 years and without metastases were eligible. After the baseline examinations, women were randomized to an active dietary intervention or to a control group. The intervention group attended six full days of life-style intervention activities (cookery classes followed by lunch, sessions of walking for 45 min and nutritional conferences) over the next six months. 213 BRCA mutation carriers completed the six-month study. Women

SUBMITTER: Pasanisi P 

PROVIDER: S-EPMC6162406 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature