Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells.

ABSTRACT: T-cell factor 4 (TCF4), together with β-catenin coactivator, functions as the major transcriptional mediator of the canonical wingless/integrated (Wnt) signaling pathway in the intestinal epithelium. The pathway activity is essential for both intestinal homeostasis and tumorigenesis. To date, several mouse models and cellular systems have been used to analyze TCF4 function. However, some findings were conflicting, especially those that were related to the defects observed in the mouse gastrointestinal tract after Tcf4 gene deletion, or to a potential tumor suppressive role of the gene in intestinal cancer cells or tumors. Here, we present the results obtained using a newly generated conditional Tcf4 allele that allows inactivation of all potential Tcf4 isoforms in the mouse t

SUBMITTER: Hrckulak D 

PROVIDER: S-EPMC6162433 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature