Ontology highlight
ABSTRACT:
SUBMITTER: Elisi GM
PROVIDER: S-EPMC6162436 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Cancers 20180914 9
Drug repurposing is a fast and consolidated approach for the research of new active compounds bypassing the long streamline of the drug discovery process. Several drugs in clinical practice have been reported for modulating the major Hippo pathway's terminal effectors, namely YAP (Yes1-associated protein), TAZ (transcriptional co-activator with PDZ-binding motif) and TEAD (transcriptional enhanced associate domains), which are directly involved in the regulation of cell growth and tissue homeost ...[more]