MiRmapper: A Tool for Interpretation of miRNA⁻mRNA Interaction Networks.

ABSTRACT: It is estimated that 30% of all genes in the mammalian cells are regulated by microRNA (miRNAs). The most relevant miRNAs in a cellular context are not necessarily those with the greatest change in expression levels between healthy and diseased tissue. Differentially expressed (DE) miRNAs that modulate a large number of messenger RNA (mRNA) transcripts ultimately have a greater influence in determining phenotypic outcomes and are more important in a global biological context than miRNAs that modulate just a few mRNA transcripts. Here, we describe the development of a tool, "miRmapper", which identifies the most dominant miRNAs in a miRNA⁻mRNA network and recognizes similarities between miRNAs based on commonly regulated mRNAs. Using a list of miRNA⁻target gene interactions and a list of DE

SUBMITTER: da Silveira WA 

PROVIDER: S-EPMC6162471 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature