Metagenomic Composition Analysis of an Ancient Sequenced Polar Bear Jawbone from Svalbard.

ABSTRACT: The sequencing of ancient DNA samples provides a novel way to find, characterize, and distinguish exogenous genomes of endogenous targets. After sequencing, computational composition analysis enables filtering of undesired sources in the focal organism, with the purpose of improving the quality of assemblies and subsequent data analysis. More importantly, such analysis allows extinct and extant species to be identified without requiring a specific or new sequencing run. However, the identification of exogenous organisms is a complex task, given the nature and degradation of the samples, and the evident necessity of using efficient computational tools, which rely on algorithms that are both fast and highly sensitive. In this work, we relied on a fast and highly sensitive tool, FALCON-meta,

SUBMITTER: Pratas D 

PROVIDER: S-EPMC6162538 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature