Oryzines A & B, Maleidride Congeners from Aspergillus oryzae and Their Putative Biosynthesis.

ABSTRACT: Aspergillus oryzae is traditionally used in East Asia for the production of food and brewing. In addition, it has been developed into a suitable host for the heterologous expression of natural product biosynthetic genes and gene clusters, enabling the functional analysis of the encoded enzymes. A. oryzae shares a 99.5% genome homology with Aspergillus flavus, but their secondary metabolomes differ significantly and various compounds unique to A. oryzae have been reported. While using A. oryzae as a host for heterologous expression experiments we discovered two new metabolites in extracts of A. oryzae M-2-3 with an unusual maleidride backbone, which were named oryzine A and B. Their structures were elucidated by high resolution mass spectrometry (HR

SUBMITTER: Wasil Z 

PROVIDER: S-EPMC6162547 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature