Tracing Early Neurodevelopment in Schizophrenia with Induced Pluripotent Stem Cells.

ABSTRACT: Schizophrenia (SCZ) is a devastating mental disorder that is characterized by distortions in thinking, perception, emotion, language, sense of self, and behavior. Epidemiological evidence suggests that subtle perturbations in early neurodevelopment increase later susceptibility for disease, which typically manifests in adolescence to early adulthood. Early perturbations are thought to be significantly mediated through incompletely understood genetic risk factors. The advent of induced pluripotent stem cell (iPSC) technology allows for the in vitro analysis of disease-relevant neuronal cell types from the early stages of human brain development. Since iPSCs capture each donor's genotype, comparison between neuronal cells derived from healthy and diseased individuals can provide important in

SUBMITTER: Ahmad R 

PROVIDER: S-EPMC6162757 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature