The prostaglandin D₂ receptor 2 pathway in asthma: a key player in airway inflammation.

ABSTRACT: Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness. The inflammatory cascade in asthma comprises a complex interplay of genetic factors, the airway epithelium, and dysregulation of the immune response.Prostaglandin D₂ (PGD₂) is a lipid mediator, predominantly released from mast cells, but also by other immune cells such as T_H2 cells and dendritic cells, which plays a significant role in the pathophysiology of asthma. PGD₂ mainly exerts its biological functions via two G-protein-coupled receptors, the PGD₂ receptor 1 (DP₁) and 2 (DP₂). The DP₂ receptor is mainly expressed by the key cells involved in type 2 immune responses, including T_H2 cells,

SUBMITTER: Domingo C 

PROVIDER: S-EPMC6162887 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature