Overexpression of GPR35 confers drug resistance in NSCLC cells by β-arrestin/Akt signaling.

ABSTRACT:

Background

Non-small-cell lung cancer (NSCLC) is the major leading cause of cancer-related death around the world. The resistance to chemotherapy limits the effects of clinical treatment. The aim of this study was to identify novel mechanisms involved in NSCLC chemoresistance.

Materials and methods

We explored the public database and commercial tissue microarray to evaluate the expression of G protein-coupled receptor 35 (GPR35). We established the chemoresistant A549 cell line to further investigate the biological function of GPR35 in vitro and in vivo. Then, we measured the altered signalings that GPR35 knocking down by Western blot assay.

Results

We demonstrated that GPR35 expression was significantly elevated in NSCLC tissues and correlated with poor prognosis. GP

SUBMITTER: Wang W 

PROVIDER: S-EPMC6163007 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature