Melatonin and Sleep in Preventing Hospitalized Delirium: A Randomized Clinical Trial.

ABSTRACT:

Purpose

Studies suggest that melatonin may prevent delirium, a condition of acute brain dysfunction occurring in 20%-30% of hospitalized older adults that is associated with increased morbidity and mortality. We examined the effect of melatonin on delirium prevention in hospitalized older adults while measuring sleep parameters as a possible underlying mechanism.

Methods

This was a randomized clinical trial measuring the impact of 3 mg of melatonin nightly on incident delirium and both objective and subjective sleep in inpatients age ≥65 years, admitted to internal medicine wards (non-intensive care units). Delirium incidence was measured by bedside nurses using the confusion assessment method. Objective sleep measurements (nighttime sleep duration, total sleep time per 24 h

SUBMITTER: Jaiswal SJ 

PROVIDER: S-EPMC6163056 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature