Functional Annotation of Caenorhabditis elegans Genes by Analysis of Gene Co-Expression Networks.

ABSTRACT: Caenorhabditis elegans (C. elegans) is a well-characterized metazoan, whose transcriptome has been profiled in different tissues, development stages, or other conditions. Large-scale transcriptomes can be reused for gene function annotation through systematic analysis of gene co-expression relationships. We collected 2101 microarray data from National Center for Biotechnology Information Gene Expression Omnibus (NCBI GEO), and identified 48 modules of co-expressed genes that correspond to tissues, development stages, and other experimental conditions. These modules provide an overview of the transcriptional organizations that may work under different conditions. By analyzing higher-order module networks, we found that nucleus and plasma membrane modules are more connected tha

SUBMITTER: Liu W 

PROVIDER: S-EPMC6163173 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature