Functional Expression of TRP Ion Channels in Endometrial Stromal Cells of Endometriosis Patients.

ABSTRACT: Endometriosis is a common gynecological disease that is characterized by the presence of functional endometrial-like lesions in the abdominal cavity. Aside from epithelial cells, these lesions consist of stromal cells that have the capacity to migrate, adhere, proliferate, and induce neuro- and lymphangiogenesis, which allows them to survive at ectopic locations. However, the exact underlying mechanisms that regulate these changes are yet to be elucidated. The common ground of these processes, however, is the second messenger, calcium. In this regard, members of the superfamily of transient receptor potential (TRP) ion channels, which are known to be calcium-permeable and expressed in the endometrium, have emerged as key regulators. Here, we assessed the molecular and functional expression

SUBMITTER: Persoons E 

PROVIDER: S-EPMC6163224 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature