Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

ABSTRACT: Akkermansia muciniphila is a mucin-degrading bacterium of the phylum Verrucomicrobia. Its abundance in the human intestinal tract is inversely correlated to several disease states. A. muciniphila resides in the mucus layer of the large intestine, where it is involved in maintaining intestinal integrity. We explore the presence of Akkermansia-like spp. based on its 16S rRNA sequence and metagenomic signatures in the human body so as to understand its colonization pattern in time and space. A. muciniphila signatures were detected in colonic samples as early as a few weeks after birth and likely could be maintained throughout life. The sites where Akkermansia-like sequences (including Verrucomicrobia phylum and/or Akkermansia spp. sequences found in t

SUBMITTER: Geerlings SY 

PROVIDER: S-EPMC6163243 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature