Actin-Myosin Interaction: Structure, Function and Drug Discovery.

ABSTRACT: Actin-myosin interactions play crucial roles in the generation of cellular force and movement. The molecular mechanism involves structural transitions at the interface between actin and myosin's catalytic domain, and within myosin's light chain domain, which contains binding sites for essential (ELC) and regulatory light chains (RLC). High-resolution crystal structures of isolated actin and myosin, along with cryo-electron micrographs of actin-myosin complexes, have been used to construct detailed structural models for actin-myosin interactions. However, these methods are limited by disorder, particularly within the light chain domain, and they do not capture the dynamics within this complex under physiological conditions in solution. Here we highlight the contributions of site-directed fl

SUBMITTER: Guhathakurta P 

PROVIDER: S-EPMC6163256 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature